KHAEMENES ACADEMY · BIOLOGY 10 · WEEK 28 · DAY 01

Allele & Genotype Frequencies

Calculate allele frequencies from genotype counts and distinguish population composition from individual genotype.

Safety and evidence boundary

Use fictional populations, cards, spreadsheets, or published aggregate data. Do not use population-genetic concepts to rank human groups or infer personal ancestry, intelligence, worth, or disease. Evolutionary mechanisms are population-level processes.

Explicit science instruction

Population genetics tracks how allele and genotype frequencies change across generations. For a diploid locus with alleles A and a, each individual contributes two allele copies. If counts are AA, Aa, aa, then frequency of A is (2AA + Aa)/(2N), and a is (2aa + Aa)/(2N).

Allele frequency belongs to a population sample; an individual does not have an “allele frequency.”

Vocabulary: allele frequency; genotype frequency; population; gene pool; diploid; generation.

Worked example with reasoning

In 100 fictional organisms: 36 AA, 48 Aa, 16 aa. A copies = 72+48=120 of 200, so p(A)=0.60; q(a)=0.40. Genotype frequencies are .36, .48, .16.

Guided question

Why do we divide allele counts by 2N in a diploid population?

Independent work

  1. Calculate frequencies for 25 AA, 50 Aa, 25 aa.
  2. Verify p+q=1.
  3. Distinguish allele and genotype frequency.
  4. State sampling limits.

Misconception check

A common allele is not necessarily dominant, advantageous, ancestral, or “better.” Frequency and dominance are different concepts.

Formative understanding check

If p=.7 in a two-allele model, q?

Worked response

.3.

Open-book formative practice only; not an official mastery attempt or grade.

Mentor evidence conference

Ask Archaemenes to challenge whether your population-level claim follows from the data and whether alternative evolutionary mechanisms remain possible.

Open Archaemenes

Teacher guidance

Foundation: use allele-count tokens. Core: calculate from counts and verify totals. Extended: compare sample versus true population frequency and sampling error.

Preserve learning evidence

Keep calculations, graphs, models, corrections and limitations in the matching Week 28 evidence field.